Opportunity Information: Apply for PAR 19 158

Bioengineering Research Grants (BRG) (R01 Clinical Trial Not Allowed) is a National Institutes of Health (NIH) discretionary grant opportunity (Funding Opportunity Number PAR-19-158) that supports collaborative, multidisciplinary bioengineering research aimed at solving clearly defined biomedical problems. The central idea is to bring together expertise from the life sciences and the physical/engineering sciences to create or refine practical solutions that can move the field forward. Projects are expected to use a bioengineering framework not just to generate knowledge, but to produce tools, methods, or technologies that can be integrated into biomedical research or practice, improved through optimization and validation, and then translated or otherwise accelerated toward real-world adoption.

The scope is intentionally broad in terms of scientific approach and project style. Applications may be design-directed (focused on building and iterating a solution), developmental (advancing early-stage concepts), discovery-driven (uncovering new phenomena enabled by engineering approaches), or hypothesis-driven (testing specific mechanistic or biological hypotheses). What ties these approaches together is the expectation of an integrative strategy where engineering principles and biological/clinical needs are addressed together rather than in parallel. The program is described as a good fit for small teams that can combine disciplines efficiently to tackle problems in basic, translational, or clinical science, while remaining non-clinical-trial in nature under this specific R01 announcement.

A major emphasis is on accelerating adoption and impact. That includes integrating promising technologies into workflows, optimizing performance for a specific use case, validating methods so they are trusted and reproducible, and translating results so they can be used by other researchers or applied in clinical or translational settings. In practice, that can mean anything from improving instrumentation or biomaterials, to advancing computational methods for biomedical data, to developing quantitative measurement techniques, to refining platforms that enable better diagnostics, monitoring, or experimental models, as long as the work remains within the “clinical trial not allowed” boundary for this announcement.

Eligibility is broad and includes many types of domestic U.S. applicants such as state, county, city/township, and special district governments; independent school districts; public and state-controlled institutions of higher education; private institutions of higher education; federally recognized Native American tribal governments; other tribal organizations; public housing authorities/Indian housing authorities; nonprofits with or without 501(c)(3) status (excluding higher education institutions in those categories); for-profit organizations (other than small businesses); and small businesses. The announcement also explicitly notes additional eligible applicant groups, including Alaska Native and Native Hawaiian Serving Institutions; Asian American Native American Pacific Islander Serving Institutions (AANAPISISs); Hispanic-serving Institutions; Historically Black Colleges and Universities (HBCUs); Tribally Controlled Colleges and Universities (TCCUs); eligible federal agencies; faith-based or community-based organizations; regional organizations; U.S. territories or possessions; and non-U.S. entities (foreign organizations), as well as Indian/Native American tribal governments other than federally recognized tribes.

The funding instrument is an NIH R01 research project grant, and the funding activity category is listed under Education, Environment, and Health. Multiple NIH CFDA numbers are associated with this opportunity (93.113, 93.121, 93.273, 93.286, 93.393, 93.394, 93.395, 93.396, 93.399, 93.846, 93.853, 93.866), reflecting the cross-cutting relevance of bioengineering across NIH institutes and program areas. The opportunity record shows an original closing date of 2022-05-07 and a creation date of 2019-01-08; award ceiling and expected award counts are not specified in the provided data.

  • The National Institutes of Health in the education, environment, health sector is offering a public funding opportunity titled "Bioengineering Research Grants (BRG) (R01 Clinical Trial Not Allowed)" and is now available to receive applicants.
  • Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.113, 93.121, 93.273, 93.286, 93.393, 93.394, 93.395, 93.396, 93.399, 93.846, 93.853, 93.866.
  • This funding opportunity was created on 2019-01-08.
  • Applicants must submit their applications by 2022-05-07. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
  • Eligible applicants include: State governments, County governments, City or township governments, Special district governments, Independent school districts, Public and State controlled institutions of higher education, Native American tribal governments (Federally recognized), Public housing authorities/Indian housing authorities, Native American tribal organizations (other than Federally recognized tribal governments), Nonprofits having a 501 (c) (3) status with the IRS, other than institutions of higher education, Nonprofits that do not have a 501 (c) (3) status with the IRS, other than institutions of higher education, Private institutions of higher education, For-profit organizations other than small businesses, Small businesses, Others.
Apply for PAR 19 158

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