Centers for Multiple Chronic Diseases Associated with Health Disparities: Prevention, Treatment, and Management (P50 Clinical Trial Required) | RFA MD 21 007

Opportunity Information: Apply for RFA MD 21 007

The National Institutes of Health (NIH) funding opportunity titled "Centers for Multiple Chronic Diseases Associated with Health Disparities: Prevention, Treatment, and Management (P50 Clinical Trial Required)" (Funding Opportunity Number RFA-MD-21-007; CFDA 93.307) is designed to build and support comprehensive, center-based research programs focused on multiple chronic diseases that disproportionately affect populations experiencing health disparities. The central goal is to strengthen coordinated, multidisciplinary research that can move beyond studying single conditions in isolation and instead address how chronic diseases co-occur, how they are prevented and treated, and how long-term management can be improved in real-world settings where disparities persist. Because this is a P50 center mechanism and explicitly states "Clinical Trial Required," applicants should expect that clinical trial activity is a required component of the proposed center, rather than optional or incidental.

This opportunity supports "comprehensive research centers," which typically implies an integrated structure with multiple interrelated projects and shared infrastructure aimed at producing a bigger, sustained impact than a standalone research grant. The emphasis spans prevention, treatment, and management, meaning applicants can propose research that reduces disease incidence, improves therapeutic approaches and outcomes, and strengthens ongoing care strategies that help individuals live better with chronic conditions over time. The framing around health disparities signals that the research should be grounded in the needs of populations that face systematic disadvantages in health outcomes, access to care, or quality of care, and that the work should be positioned to generate evidence that meaningfully reduces those inequities.

Eligible applicants are broad and include many types of U.S.-based governmental, educational, nonprofit, and private-sector organizations. Specifically listed eligible entities include state, county, and city or township governments; special district governments; independent school districts; public and state-controlled institutions of higher education; private institutions of higher education; Native American tribal governments that are federally recognized; public housing authorities and Indian housing authorities; Native American tribal organizations that are not federally recognized governments; nonprofits with 501(c)(3) status; nonprofits without 501(c)(3) status (in both cases, other than institutions of higher education); for-profit organizations other than small businesses; small businesses; and other unspecified eligible categories. The announcement also highlights additional eligible applicant types that commonly serve populations affected by health disparities, including Alaska Native and Native Hawaiian Serving Institutions, Asian American Native American Pacific Islander Serving Institutions (AANAPISIs), Hispanic-serving Institutions, Historically Black Colleges and Universities (HBCUs), Indian/Native American Tribal Governments (other than federally recognized), Tribally Controlled Colleges and Universities (TCCUs), and U.S. territories or possessions.

At the same time, the opportunity is clear about what is not allowed with respect to international participation. Non-domestic (non-U.S.) entities (foreign institutions) are not eligible to apply. In addition, non-domestic components of U.S. organizations are not eligible to apply, and foreign components (as defined by the NIH Grants Policy Statement) are not allowed. In practical terms, this means the applicant organization and the proposed work need to be fully domestic, without foreign institutional applicants, foreign subcomponents, or foreign components embedded in the project structure.

From an administrative and funding standpoint, this is a discretionary grant funding instrument within the health funding activity category, administered by NIH. The listing provides an award ceiling of $3,000,000, indicating the maximum anticipated amount per award under the opportunity. The source data shows the opportunity was created on April 14, 2021, with an original closing date of June 24, 2021, and an anticipated number of awards not specified in the provided text. Overall, the opportunity is best understood as NIH support for large, coordinated research centers that will run clinical trials and produce actionable, center-driven evidence on how to prevent, treat, and manage multiple chronic diseases in ways that reduce health disparities across affected communities.

• The National Institutes of Health in the health sector is offering a public funding opportunity titled "Centers for Multiple Chronic Diseases Associated with Health Disparities: Prevention, Treatment, and Management (P50 Clinical Trial Required)" and is now available to receive applicants.
• Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.307.
• This funding opportunity was created on 2021-04-14.
• Applicants must submit their applications by 2021-06-24. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
• Each selected applicant is eligible to receive up to $3,000,000.00 in funding.
• Eligible applicants include: State governments, County governments, City or township governments, Special district governments, Independent school districts, Public and State controlled institutions of higher education, Native American tribal governments (Federally recognized), Public housing authorities/Indian housing authorities, Native American tribal organizations (other than Federally recognized tribal governments), Nonprofits having a 501 (c) (3) status with the IRS, other than institutions of higher education, Nonprofits that do not have a 501 (c) (3) status with the IRS, other than institutions of higher education, Private institutions of higher education, For-profit organizations other than small businesses, Small businesses, Others.

Apply for RFA MD 21 007

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