HIV Prevention Among Adolescent Girls and Young Women and Other Vulnerable Youth Populations - DREAMS South | 72067425RFA00002

Opportunity Information: Apply for 72067425RFA00002

The HIV Prevention Among Adolescent Girls and Young Women and Other Vulnerable Youth Populations - DREAMS South opportunity is a USAID/South Africa (Pretoria) funding call focused on reducing new HIV infections among adolescent girls and young women (AGYW) ages 10 to 24 in South African districts with especially high HIV incidence and prevalence. The activity is framed around the idea that HIV risk for AGYW is shaped by more than one factor at a time, so the program is expected to increase access to a comprehensive, age-appropriate package of prevention services that tackle biological, behavioral, and socio-economic drivers of risk together, rather than relying on a single intervention.

Programmatically, DREAMS South emphasizes evidence-based or evidence-informed HIV prevention interventions tailored to adolescents and young adults. A key feature of the approach is improving practical access to prevention and sexual and reproductive health services, with particular prioritization of contraception availability, sexually transmitted infection (STI) treatment, and Post-Exposure Prophylaxis (PEP). In other words, the opportunity is not just about education or awareness; it is designed to strengthen the real-world service mix that helps AGYW prevent HIV and manage related health needs, while also addressing broader circumstances that increase vulnerability.

Geographically, the activity is anticipated to operate across four provinces, focusing on specific districts/metros: KwaZulu-Natal (King Cetshwayo and Ugu), Free State (Lejweleputswa and Thabo Mofutsanyane), Eastern Cape (Alfred Nzo and Buffalo City), and Western Cape (City of Cape Town). These locations are highlighted because they represent areas with the highest HIV burden, and the expectation is that concentrating resources and interventions there will contribute to a measurable reduction in HIV incidence among AGYW.

From a grants and administrative standpoint, the opportunity is a discretionary award using a Cooperative Agreement mechanism, meaning USAID expects to remain substantially involved in the program’s direction and oversight compared with a standard grant. The funding opportunity number is 72067425RFA00002, the CFDA/Assistance Listing is 98.001, and the total possible award size is substantial, with an award ceiling of $58,000,000. USAID anticipates making one award under this solicitation, which usually indicates the intent to fund a single prime implementer that can coordinate a large, multi-area, multi-intervention effort.

Eligibility is restricted to local South African entities, and applicants are directed to the Notice of Funding Opportunity (NOFO) for the detailed eligibility requirements and any additional compliance, partnership, or registration conditions. The opportunity was created on December 20, 2024, and the original closing date for applications is February 18, 2025.

• The South Africa USAID-Pretoria in the health sector is offering a public funding opportunity titled "HIV Prevention Among Adolescent Girls and Young Women and Other Vulnerable Youth Populations - DREAMS South" and is now available to receive applicants.
• Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 98.001.
• This funding opportunity was created on 2024-12-20.
• Applicants must submit their applications by 2025-02-18. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
• Each selected applicant is eligible to receive up to $58,000,000.00 in funding.
• The number of recipients for this funding is limited to 1 candidate(s).
• Eligible applicants include: Others.

Apply for 72067425RFA00002

[Watch] Creating a grant proposal using the step-by-step wizard inside the applicant portal: