Opportunity Information: Apply for 72067425RFA00002
The HIV Prevention Among Adolescent Girls and Young Women and Other Vulnerable Youth Populations - DREAMS South opportunity is a USAID/South Africa (Pretoria) funding call focused on reducing new HIV infections among adolescent girls and young women (AGYW) ages 10 to 24 in South African districts with especially high HIV incidence and prevalence. The activity is framed around the idea that HIV risk for AGYW is shaped by more than one factor at a time, so the program is expected to increase access to a comprehensive, age-appropriate package of prevention services that tackle biological, behavioral, and socio-economic drivers of risk together, rather than relying on a single intervention.
Programmatically, DREAMS South emphasizes evidence-based or evidence-informed HIV prevention interventions tailored to adolescents and young adults. A key feature of the approach is improving practical access to prevention and sexual and reproductive health services, with particular prioritization of contraception availability, sexually transmitted infection (STI) treatment, and Post-Exposure Prophylaxis (PEP). In other words, the opportunity is not just about education or awareness; it is designed to strengthen the real-world service mix that helps AGYW prevent HIV and manage related health needs, while also addressing broader circumstances that increase vulnerability.
Geographically, the activity is anticipated to operate across four provinces, focusing on specific districts/metros: KwaZulu-Natal (King Cetshwayo and Ugu), Free State (Lejweleputswa and Thabo Mofutsanyane), Eastern Cape (Alfred Nzo and Buffalo City), and Western Cape (City of Cape Town). These locations are highlighted because they represent areas with the highest HIV burden, and the expectation is that concentrating resources and interventions there will contribute to a measurable reduction in HIV incidence among AGYW.
From a grants and administrative standpoint, the opportunity is a discretionary award using a Cooperative Agreement mechanism, meaning USAID expects to remain substantially involved in the program’s direction and oversight compared with a standard grant. The funding opportunity number is 72067425RFA00002, the CFDA/Assistance Listing is 98.001, and the total possible award size is substantial, with an award ceiling of $58,000,000. USAID anticipates making one award under this solicitation, which usually indicates the intent to fund a single prime implementer that can coordinate a large, multi-area, multi-intervention effort.
Eligibility is restricted to local South African entities, and applicants are directed to the Notice of Funding Opportunity (NOFO) for the detailed eligibility requirements and any additional compliance, partnership, or registration conditions. The opportunity was created on December 20, 2024, and the original closing date for applications is February 18, 2025.Apply for 72067425RFA00002
- The South Africa USAID-Pretoria in the health sector is offering a public funding opportunity titled "HIV Prevention Among Adolescent Girls and Young Women and Other Vulnerable Youth Populations - DREAMS South" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 98.001.
- This funding opportunity was created on 2024-12-20.
- Applicants must submit their applications by 2025-02-18. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- Each selected applicant is eligible to receive up to $58,000,000.00 in funding.
- The number of recipients for this funding is limited to 1 candidate(s).
- Eligible applicants include: Others.
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Frequently Asked Questions (FAQs)
1) What is the DREAMS South funding opportunity?
The HIV Prevention Among Adolescent Girls and Young Women and Other Vulnerable Youth Populations - DREAMS South opportunity is a USAID/South Africa (Pretoria) funding call focused on reducing new HIV infections among adolescent girls and young women (AGYW) ages 10 to 24 in South Africa, particularly in districts with very high HIV incidence and prevalence.
2) Who is the primary target population for this program?
The primary target population is adolescent girls and young women (AGYW) ages 10 to 24.
3) Does the opportunity also include other groups besides AGYW?
Yes. The opportunity name references "other vulnerable youth populations," indicating the activity is intended to address HIV prevention among AGYW and other vulnerable youth populations, as described in the funding call.
4) What is the main goal of the activity?
The main goal is to reduce new HIV infections among AGYW ages 10 to 24 in selected high-burden South African districts/metros.
5) What is the overall program approach expected by USAID?
The activity is framed around the idea that HIV risk for AGYW is shaped by multiple factors at the same time. The program is expected to increase access to a comprehensive, age-appropriate package of HIV prevention services that address biological, behavioral, and socio-economic drivers together, rather than relying on a single intervention.
6) Is this opportunity mainly for HIV education and awareness activities?
No. The description emphasizes that it is not only about education or awareness. It is designed to strengthen the real-world mix of services that helps AGYW prevent HIV and manage related health needs, while also addressing broader circumstances that increase vulnerability.
7) What kinds of interventions does DREAMS South emphasize?
DREAMS South emphasizes evidence-based or evidence-informed HIV prevention interventions tailored to adolescents and young adults.
8) What services are specifically prioritized within the prevention and sexual and reproductive health package?
The opportunity highlights practical access to prevention and sexual and reproductive health services, with particular prioritization of contraception availability, sexually transmitted infection (STI) treatment, and Post-Exposure Prophylaxis (PEP).
9) Where is the program expected to operate?
The activity is anticipated to operate across four provinces in South Africa, focusing on specific districts/metros in each province.
10) Which provinces are included in the anticipated geographic focus?
The four provinces are KwaZulu-Natal, Free State, Eastern Cape, and Western Cape.
11) Which districts/metros are specifically named in the opportunity?
The named locations are:
- KwaZulu-Natal: King Cetshwayo and Ugu
- Free State: Lejweleputswa and Thabo Mofutsanyane
- Eastern Cape: Alfred Nzo and Buffalo City
- Western Cape: City of Cape Town
12) Why are these locations being targeted?
They are highlighted as areas with the highest HIV burden. The expectation is that concentrating resources and interventions in these areas will contribute to a measurable reduction in HIV incidence among AGYW.
13) What type of award mechanism will USAID use for this opportunity?
This is a discretionary award using a Cooperative Agreement mechanism.
14) What does it mean that the award is a Cooperative Agreement?
It means USAID expects to remain substantially involved in the program's direction and oversight compared with a standard grant.
15) What is the funding opportunity number for this solicitation?
The funding opportunity number is 72067425RFA00002.
16) What is the CFDA/Assistance Listing number?
The CFDA/Assistance Listing number is 98.001.
17) What is the maximum funding amount mentioned for the award?
The award ceiling is $58,000,000.
18) How many awards does USAID expect to make under this solicitation?
USAID anticipates making one award under this solicitation.
19) What does it imply that USAID anticipates making one award?
It usually indicates an intent to fund a single prime implementer that can coordinate a large, multi-area, multi-intervention effort across the identified provinces and districts/metros.
20) Who is eligible to apply?
Eligibility is restricted to local South African entities.
21) Where should applicants look for the detailed eligibility requirements?
Applicants are directed to the Notice of Funding Opportunity (NOFO) for detailed eligibility requirements and any additional compliance, partnership, or registration conditions.
22) When was this opportunity created?
The opportunity was created on December 20, 2024.
23) What is the application deadline?
The original closing date for applications is February 18, 2025.
24) Which USAID mission is issuing this opportunity?
The opportunity is issued by USAID/South Africa (Pretoria).
25) What is the expected focus of services for AGYW within the program?
The expected focus is on increasing practical access to a comprehensive, age-appropriate package of HIV prevention and sexual and reproductive health services, including prioritized access to contraception, STI treatment, and PEP, alongside interventions that address biological, behavioral, and socio-economic drivers of HIV risk.
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