Opportunity Information: Apply for RFA HL 19 010
This funding opportunity (RFA-HL-19-010) is a limited-competition cooperative agreement from the National Institutes of Health within the Department of Health and Human Services to support the Data Coordinating Center (DCC) for the Cardiothoracic Surgical Trials Network (CTSN). In practical terms, NIH is looking to fund one central coordinating hub that will organize, manage, and support the network-wide clinical research portfolio for CTSN. The award mechanism is a U01 cooperative agreement, which generally means the NIH will have substantial programmatic involvement in the project compared with a standard grant, and the work is expected to be carried out in close collaboration with NIH staff and the rest of the CTSN sites.
The CTSN renewal described in the announcement is centered on producing high-quality, collaborative randomized controlled trials and related studies in cardiothoracic surgery, while deliberately reaching beyond surgery alone. The FOA emphasizes research questions that sit at the intersection of cardiac surgery with broader cardiology and neurology care, particularly where outcomes depend on cross-specialty, team-based decision-making and management. The overall expectation is that the network will test interventions and novel therapies in the surgical context, generate evidence that can improve patient outcomes, and produce findings that can influence clinical practice in ways that are relevant and translatable to the general population, not just to highly specialized centers.
A key feature of this renewal is the explicit integration of implementation research alongside randomized trials. Rather than stopping at whether an intervention works under trial conditions, the network is expected to study how best to support uptake, long-term use, and sustainability of evidence-based practices in real-world settings. This focus is framed as especially important in areas of high disease burden, where improvements in care delivery and consistent adoption of proven strategies can have an outsized impact. In other words, CTSN is being positioned not only to generate definitive trial results, but also to help close the gap between evidence and routine practice.
Another stated goal is workforce development. The network is expected to help foster the next generation of clinical investigators and implementation researchers, reflecting an interest in building long-term capacity in rigorous trial methods, multisite collaboration, and pragmatic translation of results into clinical systems. While the FOA summary does not list specific training components, it makes clear that developing emerging researchers is part of the renewal’s mission and is meant to be embedded in the network’s activities.
Structurally, this FOA is specifically for the DCC, and it is paired with a separate companion announcement (RFA-HL-19-009) seeking applications for Linked Clinical Research Centers (LCRCs). That division signals that the CTSN model relies on multiple clinical sites enrolling participants and delivering interventions, with the DCC serving as the centralized backbone for trial coordination and network operations. The DCC would typically be expected to handle many of the functions that make complex, multisite surgical trials feasible and reliable, such as protocol and manual-of-operations development support, randomization and data systems, data collection standards, data quality assurance, safety and regulatory coordination, statistical design and analysis, reporting, and supporting network governance and communications across sites. The label “Clinical Trial Required” indicates that the funded activity is expected to include management and conduct of clinical trials rather than purely observational or preparatory work.
Eligibility is broad across government, academic, nonprofit, and for-profit entities, including institutions of higher education, hospitals or research organizations with appropriate infrastructure, and certain tribal and public housing authorities, among others. Even with broad eligibility language, the “limited competition” framing usually means only certain applicants are permitted to apply (for example, prior network participants or invitees), with the specific limitation typically detailed in the full FOA text under additional eligibility information. The opportunity is categorized under health (CFDA 93.837 and 93.840), and NIH anticipated making a single award. The posting indicates a creation date of May 16, 2018, with an original closing date of August 2, 2018. The award ceiling is listed as 0 in the summary data, which commonly reflects that the ceiling was not specified in that field rather than implying no funding; the full FOA would normally provide budget expectations or limits.
Overall, the opportunity is best understood as NIH funding one organization to serve as the operational and analytical center of a national cardiothoracic surgical trials network, with responsibilities spanning rigorous trial coordination, cross-specialty clinical research support, and an added emphasis on implementation strategies that help proven interventions move into sustained everyday care.Apply for RFA HL 19 010
- The Department of Health and Human Services, National Institutes of Health in the health sector is offering a public funding opportunity titled "Limited Competition: Cardiothoracic Surgical Trials Network (CTSN) Data Coordinating Center (U01 Clinical Trial Required)" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.837, 93.840.
- This funding opportunity was created on May 16, 2018.
- Applicants must submit their applications by Aug 02, 2018. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- The number of recipients for this funding is limited to 1 candidate(s).
- Eligible applicants include: State governments, County governments, City or township governments, Special district governments, Independent school districts, Public and State controlled institutions of higher education, Native American tribal governments (Federally recognized), Public housing authorities/Indian housing authorities, Native American tribal organizations (other than Federally recognized tribal governments), Nonprofits having a 501(c)(3) status with the IRS, other than institutions of higher education, Nonprofits that do not have a 501(c)(3) status with the IRS, other than institutions of higher education, Private institutions of higher education, For profit organizations other than small businesses, Small businesses, Others (see text field entitled Additional Information on Eligibility for clarification).
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