Opportunity Information: Apply for PAR 23 076
The NIDA Research Center of Excellence Grant Program (P50 Clinical Trial Optional), PAR-23-076, is a National Institutes of Health funding opportunity designed to build and support high-impact research centers focused on drug abuse and addiction. The program is aimed at centers that pursue research aligned with NIDA's mission across any relevant scientific area, but it places a strong emphasis on work that is genuinely innovative and transformative rather than incremental. In practical terms, NIDA is looking for centers that can push the field forward by launching new scientific directions, developing novel concepts or methods, and generating findings that meaningfully change how researchers, clinicians, and decision-makers understand and respond to substance use and addiction.
A central expectation of this P50 program is that the funded center operates as an integrated, multidisciplinary enterprise rather than a collection of disconnected projects. Proposed activities should be thematically linked, mutually reinforcing, and intentionally structured to create synergy across disciplines, investigators, and core resources. NIDA is also explicit that these centers should function as national resources, not only producing science but also actively supporting the broader community through educational and outreach activities. This can include engagement with drug abuse research communities, educational organizations, the general public, and policy makers, with the larger goal of translating research progress into wider understanding and better-informed decisions. The opportunity is "clinical trial optional," meaning applicants may propose clinical trials if appropriate for their scientific goals, but a clinical trial is not required.
The FOA also highlights workforce development as a core feature of a strong Center of Excellence. Funded centers are expected to foster career development and provide mentoring for new investigators, giving them meaningful roles within center projects rather than peripheral participation. This emphasis signals that NIDA wants these centers to serve as training grounds that help build the next generation of leaders in addiction science, while also strengthening institutional capacity to sustain impactful research over time.
Another defining goal of the program is to create centers that contribute to the field through sharing. NIDA intends these centers to accelerate progress by disseminating findings and, as appropriate, sharing data and resources so other researchers can use, validate, and build upon what the center develops. This community-resource mindset is part of what distinguishes the program from standard single-project research grants: the center is expected to have a broader footprint, helping to shape the field and enable other research efforts beyond its own immediate projects.
In terms of eligibility, the announcement is broadly open to a wide range of U.S.-based organizations, including state, county, city, and special district governments; public and state-controlled institutions of higher education; private institutions of higher education; independent school districts; federally recognized Native American tribal governments; public housing authorities/Indian housing authorities; Native American tribal organizations other than federally recognized tribal governments; nonprofit organizations with or without 501(c)(3) status; for-profit organizations other than small businesses; and small businesses. The FOA specifically calls out additional eligible applicant types such as Alaska Native and Native Hawaiian Serving Institutions, Asian American Native American Pacific Islander Serving Institutions (AANAPISIs), Hispanic-serving Institutions, Historically Black Colleges and Universities (HBCUs), Tribally Controlled Colleges and Universities (TCCUs), faith-based or community-based organizations, eligible federal government agencies, regional organizations, tribal governments that are not federally recognized, and U.S. territories or possessions. At the same time, foreign institutions (non-U.S. entities) are not eligible to apply directly, and non-U.S. components of U.S. organizations are not eligible; however, foreign components as defined by the NIH Grants Policy Statement are allowed, which generally means certain types of well-justified international collaboration may be permitted within an otherwise eligible U.S.-led application.
Key administrative details included in the posting are that the opportunity is a discretionary grant in the education and health funding activity category, associated with CFDA number 93.279. The posting lists an original closing date of November 18, 2025. An explicit award ceiling and expected number of awards are not specified in the provided source details, which is common for NIH FOAs where final budgets depend on scientific scope, project structure, and available appropriations. Overall, this program is best understood as support for ambitious, coordinated research centers that combine top-tier science, intentional cross-disciplinary integration, strong mentoring and career development, and active outreach and resource-sharing to move the addiction field forward at a national level.Apply for PAR 23 076
- The National Institutes of Health in the education, health sector is offering a public funding opportunity titled "NIDA Research Center of Excellence Grant Program (P50 Clinical Trial Optional)" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.279.
- This funding opportunity was created on 2023-01-12.
- Applicants must submit their applications by 2025-11-18. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- Eligible applicants include: State governments, County governments, City or township governments, Special district governments, Independent school districts, Public and State controlled institutions of higher education, Native American tribal governments (Federally recognized), Public housing authorities/Indian housing authorities, Native American tribal organizations (other than Federally recognized tribal governments), Nonprofits having a 501 (c) (3) status with the IRS, other than institutions of higher education, Nonprofits that do not have a 501 (c) (3) status with the IRS, other than institutions of higher education, Private institutions of higher education, For-profit organizations other than small businesses, Small businesses, Others.
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| Career Enhancement Award to Advance Research on Firearm Injury and Mortality Prevention (K18 Independent Clinical Trial Required) Apply for PAR 23 107 Funding Number: PAR 23 107 Agency: National Institutes of Health Category: Education, Health Funding Amount: Case Dependent |
| Career Enhancement Award to Advance Research on Firearm Injury and Mortality Prevention (K18 Independent Clinical Trial Not Allowed) Apply for PAR 23 108 Funding Number: PAR 23 108 Agency: National Institutes of Health Category: Education, Health Funding Amount: Case Dependent |
| Accelerating the Pace of Drug Abuse Research Using Existing Data (R21 Clinical Trial Optional) Apply for RFA DA 24 037 Funding Number: RFA DA 24 037 Agency: National Institutes of Health Category: Education, Health Funding Amount: $275,000 |
| Education Activities for Responsible Analyses of Complex, Large-Scale Data (R25- Clinical Trial Not Allowed) Apply for RFA DA 24 027 Funding Number: RFA DA 24 027 Agency: National Institutes of Health Category: Education, Health Funding Amount: $300,000 |
| Leveraging Big Data Science to Elucidate the Mechanisms of HIV Activity and Interaction with Substance Use Disorder (R21 Clinical Trials Not Allowed) Apply for RFA DA 24 009 Funding Number: RFA DA 24 009 Agency: National Institutes of Health Category: Education, Health Funding Amount: $275,000 |
| Leveraging Big Data Science to Elucidate the Mechanisms of HIV Activity and Interaction with Substance Use Disorder (R01 Clinical Trials Not Allowed) Apply for RFA DA 24 008 Funding Number: RFA DA 24 008 Agency: National Institutes of Health Category: Education, Health Funding Amount: $350,000 |
| Advancing Integrated Models (AIM) of Care to Improve Pregnancy Outcomes among Women Who Experience Persistent Disparities (R01 Clinical Trial Optional) Apply for RFA NR 23 002 Funding Number: RFA NR 23 002 Agency: National Institutes of Health Category: Education, Health Funding Amount: Case Dependent |
| Evaluating the Impact of Pandemic Era related Food and Housing Policies and Programs on Health Outcomes in Health Disparity Populations (R01 Clinical Trial Optional) Apply for RFA NR 23 003 Funding Number: RFA NR 23 003 Agency: National Institutes of Health Category: Education, Health Funding Amount: Case Dependent |
| Clinical-Community Linkages to Address Social Needs and Social Conditions to Advance Health Equity among Populations Experiencing Health Disparities: The Bridge-to-Care Initiative (R01 Clinical Trial Required) Apply for RFA NR 23 004 Funding Number: RFA NR 23 004 Agency: National Institutes of Health Category: Education, Health Funding Amount: Case Dependent |
| Ex Vivo Models for Studies at the Intersection of HIV and Poly-Substance Use (R01 Clinical Trial Not Allowed) Apply for RFA DA 24 001 Funding Number: RFA DA 24 001 Agency: National Institutes of Health Category: Education, Health Funding Amount: Case Dependent |
| Genomic Community Resources (U24 Clinical Trial Not Allowed) Apply for PAR 23 124 Funding Number: PAR 23 124 Agency: National Institutes of Health Category: Education, Health Funding Amount: Case Dependent |
| Addressing the Primary Care Needs of Cancer Survivors (U01 Clinical Trial Required) Apply for RFA CA 23 025 Funding Number: RFA CA 23 025 Agency: National Institutes of Health Category: Education, Health Funding Amount: $750,000 |
| Avenir Award Program for Research on Substance Use Disorders and HIV (DP2 Clinical Trial Optional) Apply for PAR 23 125 Funding Number: PAR 23 125 Agency: National Institutes of Health Category: Education, Health Funding Amount: Case Dependent |
| Precompetitive Collaboration on Liquid Biopsy for Early Cancer Assessment: Data Management and Coordinating Unit (U24 Clinical Trial Not Allowed) Apply for RFA CA 23 031 Funding Number: RFA CA 23 031 Agency: National Institutes of Health Category: Education, Health Funding Amount: $450,000 |
| Research With Activities Related to Diversity (ReWARD) (R01 Clinical Trial Optional) Apply for PAR 23 122 Funding Number: PAR 23 122 Agency: National Institutes of Health Category: Education, Health Funding Amount: Case Dependent |
| NIDA Avant-Garde Program for HIV and Substance Use Disorder Research (DP1 Clinical Trial Optional) Apply for PAR 23 269 Funding Number: PAR 23 269 Agency: National Institutes of Health Category: Education, Health Funding Amount: $700,000 |
| Discovery and Development of Natural Products for Cancer Interception and Prevention (UG3/UH3 Clinical Trial Not Allowed) Apply for RFA CA 23 028 Funding Number: RFA CA 23 028 Agency: National Institutes of Health Category: Education, Health Funding Amount: $250,000 |
| Impacts of climate change across the cancer control continuum (R01 Clinical Trial Optional) Apply for PAR 23 153 Funding Number: PAR 23 153 Agency: National Institutes of Health Category: Education, Health Funding Amount: Case Dependent |
| Impacts of climate change across the cancer control continuum (R21 Clinical Trial Optional) Apply for PAR 23 152 Funding Number: PAR 23 152 Agency: National Institutes of Health Category: Education, Health Funding Amount: $275,000 |
| Request for Applications (RFA): Revision Applications to Support Research on Prevention and Cessation of Menthol Cigarette Use in Populations that Experience Health Disparities (R01, Clinical Trial Optional) Apply for RFA OD 23 015 Funding Number: RFA OD 23 015 Agency: National Institutes of Health Category: Education, Health Funding Amount: $200,000 |
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