Opportunity Information: Apply for PAR 23 050
The National Institutes of Health (NIH) is offering the Clinical Studies of Mental Illness (Collaborative R01) (Clinical Trial Optional) funding opportunity (PAR-23-050), a discretionary grant program in the health area (CFDA 93.242). The purpose of this announcement is to fund collaborative, multi-site clinical studies focused on mental illness, with an emphasis on work that benefits from recruiting participants across two or more locations. The key point is that this mechanism is meant for clinical research that is not aimed at developing new treatments or testing whether treatments work. In other words, it is not intended for treatment development, efficacy trials, or effectiveness trials.
The science priorities center on collaborative clinical studies in areas such as mental health genetics, biomarker research, and clinical investigations of mental illnesses. Examples mentioned include studies of psychopathology and research on neurodevelopmental trajectories related to psychopathology. The announcement also explicitly welcomes studies of mental illnesses when they are associated with HIV/AIDS, reflecting an interest in understanding overlapping or interacting clinical and biological factors in these populations.
A defining feature of this opportunity is its expectation of genuine multi-site collaboration. Applicants are expected to use this FOA when having two or more sites is necessary to complete the study, such as when multiple locations are required to reach a large enough sample size, speed up recruitment timelines, or ensure broader diversity and representation in the participant pool. The participating sites are expected to follow a shared, common protocol so that data can be combined and compared reliably across locations. For projects that involve a large number of sites, the NIH notes that one site is typically expected to take on a coordinating role under a separate coordinating R01, handling centralized functions like data management and administrative coordination to keep the overall study consistent and well-governed.
The eligible applicant pool is broad and includes many types of U.S. and non-U.S. organizations. Eligible applicants include state, county, city or township, and special district governments; independent school districts; public and state-controlled institutions of higher education; private institutions of higher education; federally recognized Native American tribal governments; Native American tribal organizations that are not federally recognized tribal governments; public housing authorities and Indian housing authorities; nonprofits with and without 501(c)(3) status (other than institutions of higher education); for-profit organizations (other than small businesses); and small businesses. The announcement also highlights additional eligible groups such as Alaska Native and Native Hawaiian Serving Institutions, Asian American Native American Pacific Islander Serving Institutions (AANAPISI), Hispanic-serving Institutions, Historically Black Colleges and Universities (HBCUs), Tribally Controlled Colleges and Universities (TCCUs), faith-based or community-based organizations, eligible federal government agencies, regional organizations, non-domestic (non-U.S.) entities (foreign organizations), tribal governments other than federally recognized ones, and U.S. territories or possessions.
The funding instrument is an R01 research project grant, used here to support coordinated, protocol-driven clinical research carried out across multiple sites. While the listing indicates the clinical trial component is optional, the intent is clearly to support clinical studies that generate robust, generalizable insights into mental illness through collaboration, harmonized methods, and improved recruitment reach. The original closing date listed for this opportunity is January 7, 2026, and the opportunity was created on December 13, 2022. The notice does not specify an award ceiling or expected number of awards in the provided text, so applicants would typically confirm budgets, limits, and submission details directly in the full FOA and NIH application instructions.Apply for PAR 23 050
- The National Institutes of Health in the health sector is offering a public funding opportunity titled "Clinical Studies of Mental Illness (Collaborative R01) (Clinical Trial Optional)" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.242.
- This funding opportunity was created on 2022-12-13.
- Applicants must submit their applications by 2026-01-07. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- Eligible applicants include: State governments, County governments, City or township governments, Special district governments, Independent school districts, Public and State controlled institutions of higher education, Native American tribal governments (Federally recognized), Public housing authorities/Indian housing authorities, Native American tribal organizations (other than Federally recognized tribal governments), Nonprofits having a 501 (c) (3) status with the IRS, other than institutions of higher education, Nonprofits that do not have a 501 (c) (3) status with the IRS, other than institutions of higher education, Private institutions of higher education, For-profit organizations other than small businesses, Small businesses, Others.
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| NIH StrokeNet- Regional Coordinating Stroke Centers for year 2023 (U24 - Clinical Trials Not Allowed) Apply for RFA NS 23 010 Funding Number: RFA NS 23 010 Agency: National Institutes of Health Category: Health Funding Amount: $1,750,000 |
| NIH StrokeNet National Coordinating Center for year 2023 (U01 Clinical Trials Not Allowed) Apply for RFA NS 23 009 Funding Number: RFA NS 23 009 Agency: National Institutes of Health Category: Health Funding Amount: $1,750,000 |
| NIH StrokeNet National Data Management Center for year 2023 (U01 Clinical Trials Not Allowed) Apply for RFA NS 23 008 Funding Number: RFA NS 23 008 Agency: National Institutes of Health Category: Health Funding Amount: $1,000,000 |
| Research Networks to Promote Multidisciplinary Mechanistic Studies on Music-Based Interventions for Pain or Alzheimers Disease and Alzheimers Disease Related Dementias (AD/ADRD) (U24 Clinical Trial Optional) Apply for RFA AT 23 009 Funding Number: RFA AT 23 009 Agency: National Institutes of Health Category: Health Funding Amount: $300,000 |
| Limited Competition: Renewal of Centers of Biomedical Research Excellence (COBRE) (Phase 2) (P20 - Clinical Trial Optional) Apply for PAR 23 063 Funding Number: PAR 23 063 Agency: National Institutes of Health Category: Health Funding Amount: $1,500,000 |
| Biomedical Research Facilities (C06 Clinical Trial Not Allowed) Apply for PAR 23 045 Funding Number: PAR 23 045 Agency: National Institutes of Health Category: Health Funding Amount: $8,000,000 |
| Autoimmunity Centers of Excellence, Basic Research Program (U19 Clinical Trial Not Allowed) Apply for RFA AI 22 070 Funding Number: RFA AI 22 070 Agency: National Institutes of Health Category: Health Funding Amount: $150,000 |
| Autoimmunity Centers of Excellence, Clinical Research Program (UM1 Clinical Trial Required) Apply for RFA AI 22 071 Funding Number: RFA AI 22 071 Agency: National Institutes of Health Category: Health Funding Amount: $150,000 |
| AHRQ and PCORI Learning Health System Embedded Scientist Training and Research Centers (P30) Apply for RFA HS 23 001 Funding Number: RFA HS 23 001 Agency: Agency for Health Care Research and Quality Category: Health Funding Amount: Case Dependent |
| Pilot Studies for the Spectrum of Alzheimers Disease/Alzheimers Disease-Related Dementias and Age-Related Cognitive Decline (R61 Clinical Trial Optional) Apply for PAR 23 083 Funding Number: PAR 23 083 Agency: National Institutes of Health Category: Health Funding Amount: $325,000 |
| Early and Late Stage Clinical Trials for the Spectrum of Alzheimers Disease/Alzheimers Related Dementias and Age-Related Cognitive Decline (R01 Clinical Trial Optional) Apply for PAR 23 081 Funding Number: PAR 23 081 Agency: National Institutes of Health Category: Health Funding Amount: Case Dependent |
| Understanding the Supply of Professional Dementia Care Providers and Their Decisions (U54 Clinical Trial Not Allowed) Apply for RFA AG 24 024 Funding Number: RFA AG 24 024 Agency: National Institutes of Health Category: Health Funding Amount: Case Dependent |
| Limited Competition: Brain Tissue Resource Center for Alcohol Research (R28 Clinical Trial Not Allowed) Apply for PAR 23 068 Funding Number: PAR 23 068 Agency: National Institutes of Health Category: Health Funding Amount: Case Dependent |
| NIAMS Resource-based Centers for Bone, Muscle and Orthopaedic Research (P30 - Clinical Trial Not Allowed) Apply for RFA AR 24 002 Funding Number: RFA AR 24 002 Agency: National Institutes of Health Category: Health Funding Amount: $500,000 |
| NIAMS Skin Biology and Diseases Resource-based Centers (P30 - Clinical Trial Not Allowed) Apply for RFA AR 24 001 Funding Number: RFA AR 24 001 Agency: National Institutes of Health Category: Health Funding Amount: $500,000 |
| Bidirectional Influences Between Adolescent Social Media Use and Mental Health (R01 Clinical Trial Optional) Apply for RFA MH 23 115 Funding Number: RFA MH 23 115 Agency: National Institutes of Health Category: Health Funding Amount: Case Dependent |
| Bidirectional Influences Between Adolescent Social Media Use and Mental Health (R21 Clinical Trial Optional) Apply for RFA MH 23 116 Funding Number: RFA MH 23 116 Agency: National Institutes of Health Category: Health Funding Amount: $275,000 |
| HEAL Commercialization Readiness Pilot (CRP) Program: Embedded Entrepreneurs for Small Businesses in Pain Management (SB1 Clinical Trial Not Allowed) Apply for PAR 23 069 Funding Number: PAR 23 069 Agency: National Institutes of Health Category: Health Funding Amount: $400,000 |
| Research Centers in Minority Institutions (RCMI) (U54 Clinical Trial Optional) Apply for RFA MD 23 001 Funding Number: RFA MD 23 001 Agency: National Institutes of Health Category: Health Funding Amount: $3,500,000 |
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