Opportunity Information: Apply for CDC RFA GH21 2143
This funding opportunity, titled "Strengthening HIV Treatment, Laboratory Services, Medication Assisted Therapy, and Program Monitoring in Ukraine under PEPFAR," is a CDC cooperative agreement (Funding Opportunity Number: CDC RFA GH21-2143; CFDA: 93.067) aimed at improving Ukraine's national HIV response, particularly for the key populations most affected by the epidemic. Although the notice lists an Award Ceiling for Year 1 as 0 (meaning no fixed upper limit is set in the announcement), CDC indicates it anticipates approximately $3,000,000 in total funding for the first fiscal year, contingent on the availability of funds. The program expects to make one award. The opportunity was posted March 29, 2021, with an original application deadline of May 28, 2021 (applications due by 11:59 p.m. ET). Eligibility is broadly described as "Others" with more detail referenced in the full announcement.
The public health need driving the award is Ukraine's concentrated HIV epidemic, which disproportionately affects key populations, especially people who inject drugs (PWID) and men who have sex with men (MSM). The announcement cites an estimated 220,000 people living with HIV (PLHIV) in Ukraine. PEPFAR's ongoing support in-country has focused on expanding and sharpening HIV case-finding approaches such as index testing (including for sexual and needle-sharing partners) and social network testing, alongside increasing access to prevention tools like pre-exposure prophylaxis (PrEP). In parallel, PEPFAR has supported medication assisted therapy (MAT) for PWID as a critical harm reduction and HIV prevention/treatment-adjacent intervention, as well as improved access to World Health Organization (WHO)-recommended first-line antiretroviral therapy (ART) regimens and service delivery strategies designed to strengthen retention in care and increase viral suppression.
A central thrust of this NOFO is to strengthen the "enabling environment" for HIV programming at the national level and to fully implement an HIV electronic data entry and monitoring system referred to as the HIV MIS. In practical terms, the award is intended to help Ukraine move toward more complete, timely, and usable program and clinical data so that policy decisions, resource allocation, and service delivery improvements can be driven by evidence rather than fragmented reporting. The emphasis on an enabling policy environment signals that the work is not limited to clinic-level improvements; it also targets national systems, governance, and standardization that make effective HIV programming sustainable at scale.
The technical strategy described in the announcement includes several interconnected components. First, CDC/PEPFAR intends for the recipient to provide targeted technical assistance (TA) to HIV testing and treatment providers to improve the quality and effectiveness of HIV services across the continuum of care, from diagnosis through sustained treatment and viral suppression. Second, the NOFO calls for establishing a National MAT Hub, with the explicit goal of ensuring government leadership in scaling up MAT, rather than relying primarily on external partners. This hub concept suggests a centralized mechanism to coordinate standards, training, monitoring, supply and service delivery expectations, and overall scale-up planning for MAT nationwide. Third, the award supports enhancement of laboratory capacity, reflecting the role of labs in accurate diagnosis, viral load monitoring, and broader program quality, including the ability to track outcomes reliably.
A major additional focus area is national strengthening of surveillance, research, and epidemiology (SRE). The announcement highlights improvements in HIV case-based surveillance and mortality surveillance, indicating an intent to better track individual-level case outcomes and deaths to understand gaps, improve follow-up, and refine national estimates. It also mentions epidemic modeling, which is typically used to forecast trends, estimate unmet need, and compare the likely impact of different intervention strategies. Another stated priority is routine key population (KP) cascade monitoring that draws on both program and medical data, aiming to produce more accurate and actionable cascades (diagnosed, on treatment, virally suppressed) specifically for populations such as PWID and MSM. The inclusion of HIV drug resistance (DR) work underscores the need to detect and respond to resistance patterns that can undermine first-line regimens and threaten long-term treatment effectiveness.
Across all these elements, the overarching objective is capacity building and national-level strengthening that pushes Ukraine toward the UNAIDS 95-95-95 targets: 95% of people living with HIV knowing their status, 95% of those diagnosed receiving sustained ART, and 95% of those on ART achieving viral suppression. By improving testing strategies, treatment quality and retention, MAT leadership and scale, laboratory systems, and the data and surveillance backbone (including HIV MIS and drug resistance monitoring), the opportunity is framed as a comprehensive effort to maintain epidemic control in Ukraine through stronger systems, better data, and more effective, targeted service delivery for the populations most affected.Apply for CDC RFA GH21 2143
- The Department of Health and Human Services, Centers for Disease Control - CGH in the health sector is offering a public funding opportunity titled "Strengthening HIV Treatment, Laboratory Services, Medication Assisted Therapy, and Program Monitoring in Ukraine under the President's Emergency Plan for AIDS Relief (PEPFAR)" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 93.067.
- This funding opportunity was created on Mar 29, 2021.
- Applicants must submit their applications by May 28, 2021 Electronically submitted applications must be submitted no later than 1159 p.m., ET, on the listed application due date.. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- The number of recipients for this funding is limited to 1 candidate(s).
- Eligible applicants include: Others (see text field entitled Additional Information on Eligibility for clarification).
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Frequently Asked Questions (FAQs)
1) What is the title of this funding opportunity?
The funding opportunity is titled "Strengthening HIV Treatment, Laboratory Services, Medication Assisted Therapy, and Program Monitoring in Ukraine under PEPFAR."
2) What agency is offering this award and what type of award is it?
This is a CDC cooperative agreement under PEPFAR.
3) What are the funding identifiers (Funding Opportunity Number and CFDA)?
Funding Opportunity Number (NOFO): CDC RFA GH21-2143
CFDA: 93.067
4) What is the main purpose of the award?
The award is intended to strengthen Ukraine's national HIV response, with a focus on improving HIV treatment and service quality, laboratory capacity, medication assisted therapy (MAT) systems, and national program monitoring and data systems (including the HIV MIS), particularly for key populations most affected by HIV.
5) What public health need is this opportunity responding to?
The opportunity responds to Ukraine's concentrated HIV epidemic, which disproportionately affects key populations, especially people who inject drugs (PWID) and men who have sex with men (MSM). The announcement cites an estimated 220,000 people living with HIV (PLHIV) in Ukraine.
6) Which populations are emphasized in the program description?
The program emphasizes key populations most affected by HIV, specifically including PWID and MSM, and prioritizes approaches that improve cascades and outcomes for these groups.
7) How much funding is expected for the first year?
Although the notice lists an Award Ceiling for Year 1 as 0 (meaning no fixed upper limit is set in the announcement), CDC indicates it anticipates approximately $3,000,000 in total funding for the first fiscal year, contingent on the availability of funds.
8) What does it mean that the Year 1 award ceiling is listed as 0?
Based on the notice description, a Year 1 award ceiling of 0 indicates the announcement does not set a fixed upper limit in the posting, while CDC separately states it anticipates about $3,000,000 for the first fiscal year (subject to funds availability).
9) How many awards does CDC expect to make?
The opportunity expects to make one award.
10) When was the opportunity posted and what was the application deadline?
Posted: March 29, 2021
Original application deadline: May 28, 2021 (applications due by 11:59 p.m. ET).
11) Who is eligible to apply?
Eligibility is described broadly as "Others", with additional detail referenced in the full announcement.
12) What is PEPFAR supporting in Ukraine that relates to this award?
The description notes PEPFAR has supported expanded HIV case-finding approaches (such as index testing and social network testing), increased access to prevention tools like PrEP, expansion of MAT for PWID, improved access to WHO-recommended first-line ART regimens, and service delivery strategies designed to strengthen retention in care and increase viral suppression.
13) What is meant by strengthening the "enabling environment" for HIV programming?
In this opportunity, strengthening the enabling environment signals a focus on national-level systems and conditions that make effective HIV programming sustainable at scale, including governance, standardization, policy-related supports, and the national data and monitoring backbone, not just clinic-level service improvements.
14) What is the HIV MIS mentioned in the announcement?
The HIV MIS is described as an HIV electronic data entry and monitoring system. A central thrust of the NOFO is to fully implement this system to improve completeness, timeliness, and usability of HIV program and clinical data.
15) Why is the HIV MIS a major focus of the award?
The award emphasizes improving national data so policy decisions, resource allocation, and service delivery improvements can be driven by evidence rather than fragmented reporting, enabling more complete and timely monitoring of program performance and outcomes.
16) What types of technical assistance (TA) are expected?
The NOFO intends for the recipient to provide targeted TA to HIV testing and treatment providers to improve quality and effectiveness across the HIV continuum of care, from diagnosis through sustained treatment and viral suppression.
17) What is the National MAT Hub and what is its goal?
The NOFO calls for establishing a National MAT Hub with the explicit goal of ensuring government leadership in scaling up MAT, rather than relying primarily on external partners. The hub concept suggests a centralized mechanism to coordinate standards, training, monitoring, supply and service delivery expectations, and scale-up planning nationwide.
18) How does MAT fit within the overall HIV strategy described?
MAT is described as a critical harm reduction and HIV prevention/treatment-adjacent intervention for PWID, complementing HIV testing, ART access, and retention strategies.
19) What laboratory-related activities are emphasized?
The award supports enhancement of laboratory capacity, reflecting the importance of labs for accurate diagnosis, viral load monitoring, and reliable tracking of outcomes as part of broader program quality.
20) What is included under surveillance, research, and epidemiology (SRE) strengthening?
The NOFO highlights national strengthening of SRE, including improvements in HIV case-based surveillance and mortality surveillance, as well as epidemic modeling to forecast trends, estimate unmet need, and compare likely impacts of intervention strategies.
21) What does routine key population (KP) cascade monitoring involve in this announcement?
It involves routine monitoring of KP cascades (for example, diagnosed, on treatment, virally suppressed) using both program and medical data to produce more accurate and actionable cascades for key populations such as PWID and MSM.
22) Why does the opportunity mention HIV drug resistance (DR)?
The inclusion of HIV drug resistance work reflects the need to detect and respond to resistance patterns that can undermine first-line regimens and threaten long-term treatment effectiveness.
23) What HIV service delivery outcomes is the program trying to improve?
The program aims to strengthen HIV case-finding, treatment quality, retention in care, and viral suppression, supported by improved lab services, MAT leadership and scale-up, and stronger monitoring and surveillance systems.
24) What global targets are referenced as an overarching objective?
The opportunity is framed around helping Ukraine move toward the UNAIDS 95-95-95 targets: 95% of PLHIV knowing their status, 95% of those diagnosed receiving sustained ART, and 95% of those on ART achieving viral suppression.
25) Is this opportunity focused only on clinics and direct service delivery?
No. While it includes improving provider performance across the care continuum, a central focus is national-level strengthening, including the enabling environment, national coordination for MAT (via the National MAT Hub), laboratory systems, and national monitoring and surveillance infrastructure (including the HIV MIS).
26) What is the expected emphasis on data use and decision-making?
The NOFO emphasizes moving toward more complete, timely, and usable program and clinical data so that national decisions on policy, resource allocation, and service delivery improvements are driven by evidence.
27) What HIV testing approaches are highlighted in the context description?
The context description highlights HIV case-finding approaches such as index testing (including testing sexual and needle-sharing partners) and social network testing.
28) What prevention tool is specifically mentioned?
Pre-exposure prophylaxis (PrEP) is specifically mentioned as a prevention tool that PEPFAR has supported increasing access to.
29) What ART guidance is referenced?
The announcement references improving access to World Health Organization (WHO)-recommended first-line antiretroviral therapy (ART) regimens.
30) What is the relationship between monitoring systems and program performance in this NOFO?
The NOFO links stronger monitoring systems (including HIV MIS, case-based and mortality surveillance, and KP cascade monitoring) to better identification of gaps, improved follow-up, refined national estimates, and more effective targeting of services to maintain epidemic control.
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