Opportunity Information: Apply for HT9425 23 S TBIPH2
The DoD Traumatic Brain Injury and Psychological Health (TBIPHRP) Focused Program Award (FPA) is a large, team-based funding opportunity from the Department of Defense (managed through the U.S. Army Medical Research Acquisition Activity, USAMRAA) aimed at speeding up practical solutions for traumatic brain injury (TBI) and psychological health challenges that matter to Service Members, their families, and Veterans. The core idea is to fund an integrated, multidisciplinary program that tackles one clearly defined, high-impact problem (called the "overarching challenge") within at least one sub-area of one of the program's three FY23 focus areas. Rather than supporting disconnected studies, the FPA is designed to push a coordinated set of projects toward real clinical or operational impact, such as new or improved health care products, technologies, and practice guidelines.
A defining feature of this mechanism is that applicants must build a synergistic program made up of multiple distinct research projects led by individual project leaders, all aligned to the same overarching challenge. The program encourages (and effectively expects) a minimum of four projects, with a clinical research or clinical trial component encouraged as part of the overall package, although proposals with more or fewer than four projects can be considered if they still fit the intent of the award. Each project must be scientifically strong on its own, but the projects also need to reinforce each other so that the combined effort can produce outcomes that would not be achievable by any single project operating independently. At the same time, the award is not meant to fund a chain of projects where later projects only work if earlier ones succeed; each project should stand alone and contribute meaningfully even if another project encounters problems. The program also welcomes proposals that examine multiple hypotheses or perspectives around the same central question, as long as the work remains coordinated and clearly tied to solving the overarching challenge.
In terms of what research is allowed, the FPA supports applied, preclinical, and clinical research, including clinical trials. Clinical trials can focus on evaluating promising new products, new uses for existing interventions, pharmacologic agents (drugs or biologics), devices, clinical guidance, and emerging approaches and technologies. The scope also explicitly includes hypothesis-driven health services research, implementation science, and follow-up care research, reflecting an interest not only in discovering what works, but also in how to deliver it effectively in real-world settings. Proposed trials are expected to be positioned as feasibility studies or as work that informs the design of later, more definitive efficacy trials in relevant patient populations. Another important boundary is that basic research is not the target for this mechanism; applicants are expected to provide preliminary data for each project and show a clear intention to move toward translational and clinical application during the performance period.
Because the award is structured as a focused program rather than a single-study grant, the application must include a detailed implementation plan. This plan needs to lay out critical milestones, describe the resources and innovations that will be used to reach them, and explain how progress will be monitored both at the project level and at the overall program level. Where appropriate, a robust statistical plan and statistical expertise are expected, signaling that the DoD is looking for well-powered, well-governed studies with clear decision points. Applicants are encouraged to use an External Advisory Board, but they must avoid conflicts of interest during peer review by not contacting, recruiting, or naming specific advisory board members in the application itself. For multi-institution collaborations, the proposal must also spell out how the team will communicate, how data and specimens will be transferred and managed, and how any resulting data, specimens, or products will be handled. A formal intellectual property and material property plan agreed to by participating organizations is required as part of the supporting documentation, reflecting the program's emphasis on translational outputs and real-world deployment.
Leadership expectations are significant. The overall program is led by a Principal Investigator who has demonstrated success running large, focused collaborative efforts, and the PI must commit at least 20 percent effort to the award. The PI is expected to actively create a collaborative environment that supports innovation and meaningfully engages all team members. Each research project must have an identified project leader, and the combined team should be multidisciplinary, with complementary expertise that adds up to something stronger than the sum of its parts. The DoD also builds in ongoing program involvement: the TBIPHRP Science Officer assigned to the award should be invited to participate in team meetings (for example, annual full-team meetings), and the plan for those meetings should be described in the application.
The program also includes a formal checkpoint: after the conclusion of year 2, the PI must present progress at a Milestone Meeting in the National Capital Area. The PI can bring up to three additional team members. Attendance includes TBIPHRP program leadership (such as the Programmatic Panel), CDMRP staff, the USAMRAA grants or contracts officer, and other DoD stakeholders. This structure emphasizes accountability, milestone-driven execution, and clear movement toward deliverables that the military health system can potentially use.
Relevance to military health is not a side note; it is a central review and programmatic consideration. Applications are expected to show direct relevance to health and readiness needs for Service Members, their families, and Veterans. Examples of strong relevance include addressing a psychological health or TBI issue that affects readiness or long-term functioning, producing knowledge or tools that can be implemented in both military and civilian settings (dual-use), using military or Veteran populations or datasets when appropriate, and collaborating with DoD or VA investigators. The opportunity explicitly encourages partnerships between military or Veteran institutions and non-military institutions, since those collaborations can combine access to unique populations and infrastructure with specialized academic or industry expertise.
If an application relies on access to DoD or VA populations, resources, or databases, it must explain the status of that access at the time of submission and provide a plan to maintain access throughout the study. A key practical point is that CDMRP will not act as the government sponsor or signatory for access agreements, so applicants must arrange permissions and collaborations themselves. In some cases, access to restricted DoD or VA resources may only be possible through collaboration with a DoD or VA investigator who has a substantial role in the work, and non-DoD/non-VA investigators should plan accordingly. The opportunity also flags that human research with military populations can involve unique rules, including limits on participant compensation and additional protections or prohibitions for certain groups (for example, military families or specific operational communities), and applicants are expected to understand and comply with those requirements.
From an administrative standpoint, this is a discretionary funding opportunity under DoD, using grant and cooperative agreement instruments, associated with CFDA 12.420. Eligibility is described as unrestricted (open to any entity type), subject to any clarifications in the full announcement. The anticipated direct cost budget for the full period of performance is capped at $5.0 million, and the program anticipated making around three awards. For the FY23 cycle described, the opportunity was posted April 27, 2023, with an original closing date of September 28, 2023, and the DoD indicated awards would be made no later than September 30, 2024.Apply for HT9425 23 S TBIPH2
- The Department of Defense, Dept. of the Army -- USAMRAA in the science and technology and other research and development sector is offering a public funding opportunity titled "DoD Traumatic Brain Injury and Psychological Health, Focused Program Award" and is now available to receive applicants.
- Interested and eligible applicants and submit their applications by referencing the CFDA number(s): 12.420.
- This funding opportunity was created on Apr 27, 2023.
- Applicants must submit their applications by Sep 28, 2023. (Agency may still review applications by suitable applicants for the remaining/unused allocated funding in 2026.)
- The number of recipients for this funding is limited to 3 candidate(s).
- Eligible applicants include: Unrestricted (i.e., open to any type of entity above), subject to any clarification in text field entitled Additional Information on Eligibility.
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FAQs: DoD TBIPHRP Focused Program Award (FPA)
What is the TBIPHRP Focused Program Award (FPA)?
The DoD Traumatic Brain Injury and Psychological Health (TBIPHRP) Focused Program Award (FPA) is a large, team-based funding opportunity managed through the U.S. Army Medical Research Acquisition Activity (USAMRAA). It is designed to speed up practical solutions for traumatic brain injury (TBI) and psychological health challenges that affect Service Members, their families, and Veterans, with an emphasis on real clinical or operational impact.
What is the main goal of this award mechanism?
The goal is to fund an integrated, multidisciplinary program that tackles one clearly defined, high-impact problem (the "overarching challenge") within at least one sub-area of one of the program's three FY23 focus areas, and to move toward deliverables such as new or improved health care products, technologies, and practice guidelines.
How is the FPA different from a typical single-study research grant?
Instead of supporting disconnected studies, the FPA supports a coordinated program made up of multiple distinct research projects that are designed to work together in a synergistic way. The expectation is that the combined program achieves outcomes that no single project could produce on its own.
How many projects are expected in an FPA application?
The program encourages (and effectively expects) a minimum of four distinct projects led by individual project leaders. Proposals with more or fewer than four projects can be considered if they still meet the intent of the award.
Do the projects have to depend on each other in sequence?
No. The award is not intended to fund a chain of projects where later projects only work if earlier projects succeed. Each project should stand on its own scientifically and still contribute meaningfully even if another project encounters problems.
What does "synergy" mean in the context of this program?
Synergy means the projects reinforce each other and are coordinated around the same overarching challenge, so that the overall program can produce stronger, more impactful outcomes than any project operating independently.
Can the program test multiple hypotheses or different perspectives?
Yes. The program welcomes proposals that examine multiple hypotheses or perspectives, as long as they remain coordinated and clearly tied to solving the overarching challenge.
What types of research are supported under the FPA?
The FPA supports applied, preclinical, and clinical research, including clinical trials. It also explicitly includes hypothesis-driven health services research, implementation science, and follow-up care research.
Are clinical trials allowed under this funding opportunity?
Yes. Clinical trials are allowed and encouraged as part of the overall package. Trials may evaluate promising new products, new uses for existing interventions, pharmacologic agents (drugs or biologics), devices, clinical guidance, and emerging approaches and technologies.
What kind of clinical trial positioning does the program expect?
Proposed trials are expected to be positioned as feasibility studies or as work that informs the design of later, more definitive efficacy trials in relevant patient populations.
Is basic research supported?
Basic research is not the target of this mechanism. Applicants are expected to provide preliminary data for each project and to show clear intent to move toward translational and clinical application during the performance period.
Is preliminary data required?
Yes. Applicants are expected to provide preliminary data for each project, consistent with the program's emphasis on applied and translational outcomes rather than basic discovery work.
What is an "implementation plan," and why is it required?
The application must include a detailed implementation plan because the award is structured as a focused program rather than a single study. The plan should outline critical milestones, the resources and innovations used to reach them, and how progress will be monitored at both the individual project level and the overall program level.
Are statistics and power considerations emphasized?
Yes. Where appropriate, a robust statistical plan and statistical expertise are expected, reflecting an emphasis on well-governed studies with clear decision points and milestone-driven execution.
Is an External Advisory Board required?
An External Advisory Board is encouraged, but applicants must avoid conflicts of interest during peer review by not contacting, recruiting, or naming specific advisory board members in the application.
What collaboration details are expected for multi-institution teams?
For multi-institution collaborations, the proposal must describe how the team will communicate, how data and specimens will be transferred and managed, and how resulting data, specimens, or products will be handled.
Is an intellectual property and material property plan required?
Yes. A formal intellectual property and material property plan agreed to by participating organizations is required as supporting documentation, consistent with the program's focus on translational outputs and real-world deployment.
Who leads the overall program, and what are the effort expectations?
The program is led by a Principal Investigator (PI) with demonstrated success running large, focused collaborative efforts. The PI must commit at least 20 percent effort to the award and is expected to actively foster collaboration and innovation across the team.
Does each project need its own leader?
Yes. Each research project must have an identified project leader, and the overall team is expected to be multidisciplinary with complementary expertise.
What is the role of the TBIPHRP Science Officer after award?
The TBIPHRP Science Officer assigned to the award should be invited to participate in team meetings (for example, annual full-team meetings), and the application should describe the plan for those meetings.
Is there a required in-person meeting during the performance period?
Yes. After the conclusion of year 2, the PI must present program progress at a Milestone Meeting in the National Capital Area and may bring up to three additional team members.
Who attends the Year 2 Milestone Meeting?
Attendance includes TBIPHRP program leadership (such as the Programmatic Panel), CDMRP staff, the USAMRAA grants or contracts officer, and other DoD stakeholders.
How important is military health relevance in review and selection?
Military health relevance is a central review and programmatic consideration. Applications are expected to show direct relevance to health and readiness needs for Service Members, their families, and Veterans.
What are examples of strong military relevance mentioned in the opportunity?
Examples include addressing psychological health or TBI issues that affect readiness or long-term functioning; producing knowledge or tools usable in both military and civilian settings (dual-use); using military or Veteran populations or datasets when appropriate; and collaborating with DoD or VA investigators.
Are partnerships between military/VA and non-military institutions encouraged?
Yes. The opportunity explicitly encourages partnerships between military or Veteran institutions and non-military institutions to combine access to unique populations and infrastructure with specialized academic or industry expertise.
If a project needs access to DoD or VA populations or databases, what must be included in the application?
The application must explain the status of access at the time of submission and provide a plan to maintain access throughout the study.
Will CDMRP act as the government sponsor or signatory for access agreements?
No. CDMRP will not act as the government sponsor or signatory for access agreements, so applicants must arrange permissions and collaborations themselves.
When might collaboration with a DoD or VA investigator be necessary?
In some cases, access to restricted DoD or VA resources may only be possible through collaboration with a DoD or VA investigator who has a substantial role in the work. Non-DoD/non-VA investigators are expected to plan accordingly.
Are there special rules for human research involving military populations?
Yes. The opportunity notes that human research with military populations can involve unique rules, including limits on participant compensation and additional protections or prohibitions for certain groups (for example, military families or specific operational communities). Applicants are expected to understand and comply with these requirements.
What funding instruments are used for this opportunity?
This is a discretionary DoD funding opportunity using grant and cooperative agreement instruments.
What is the CFDA number for this program?
The opportunity is associated with CFDA 12.420.
Who is eligible to apply?
Eligibility is described as unrestricted (open to any entity type), subject to any clarifications in the full announcement.
What is the budget cap for the full period of performance?
The anticipated direct cost budget is capped at $5.0 million for the full period of performance.
How many awards were anticipated for this cycle?
The program anticipated making around three awards.
When was the opportunity posted, and what were the key dates provided?
For the FY23 cycle described, the opportunity was posted on April 27, 2023, with an original closing date of September 28, 2023. The DoD indicated awards would be made no later than September 30, 2024.
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| DoD Traumatic Brain Injury and Psychological Health, Health Services Research Award Apply for HT9425 23 TBIPHRP HSRA Funding Number: HT9425 23 TBIPHRP HSRA Agency: Department of Defense, Dept. of the Army -- USAMRAA Category: Science and Technology and other Research and Development Funding Amount: Case Dependent |
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